Fig. 7: Integrated analysis on RNA-Seq and ChIP-Seq. | npj Breast Cancer

Fig. 7: Integrated analysis on RNA-Seq and ChIP-Seq.

From: Multidimensional quantitative phenotypic and molecular analysis reveals neomorphic behaviors of p53 missense mutants

Fig. 7

a Gene expression levels, shown as log2(TPM), in each p53 mutant cell line (y axis) were compared to the mean expression levels in the other 9 mutant p53 expressing cell lines (x axis), and the differentially expressed genes (DEG, Z score-converted q < 0.05) were color-coded according to the correlation between expression levels and invasiveness across all cell lines. To examine the impact of p53 binding on the direction and the degree of expressional changes, the promoter-targeted genes identified by ChIP-Seq for each p53 mutant are highlighted with black border. b The numbers of promoter-targeted (in orange) and non-targeted (black) DEGs by each p53 mutant are shown. c Promoter-targeted genes (peak detection q < 0.05, in black) by WT and mutant p53 proteins in the Hippo/YAP/TAZ and the SREBP pathways are displayed as heat maps.

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