Fig. 6: A functional integrin binding domain is necessary to prevent early tumor onset in ∆16HER2/EMI1 KO mice. | npj Breast Cancer

Fig. 6: A functional integrin binding domain is necessary to prevent early tumor onset in ∆16HER2/EMI1 KO mice.

From: Loss of the extracellular matrix glycoprotein EMILIN1 accelerates Δ16HER2-driven breast cancer initiation in mice

Fig. 6: A functional integrin binding domain is necessary to prevent early tumor onset in ∆16HER2/EMI1 KO mice.The alternative text for this image may have been generated using AI.

a Hematoxylin and eosin pictures (top) and immunofluorescence images of EMILIN1 (green) of mammary glands collected from ∆16HER2 WT (left), ∆16HER2/EMI1 KO (middle), and ∆16HER2/EMI1 KOtg (right) mice at 11 W of age. At least three mice per genotype were evaluated. TO-PRO was used to stain nuclei in immunofluorescent images. Scale bar 50 µm. b Graph report the onset of palpable tumors derived from ∆16HER2 WT (black line), ∆16HER2/EMI1 KO (red line), and ∆16HER2/EMI1 KOtg (blue line) mice. At least 14 animals per genotype were evaluated. In all graphs, significance was calculated by Student t-test and indicated by a P < 0.05.

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