Fig. 1: Expression pattern of B7-H3 in BC. | npj Breast Cancer

Fig. 1: Expression pattern of B7-H3 in BC.

From: High B7-H3 expression with low PD-L1 expression identifies armored-cold tumors in triple-negative breast cancer

Fig. 1: Expression pattern of B7-H3 in BC.

a Transcriptional expression of B7-H3 para-tumor (n = 114) and tumor (n = 1104) tissues in the TCGA cohort. Data presented as mean ± SD. Significance was calculated with Student’s t test. b, c Representative images uncovering B7-H3 expression in para-tumor (n = 6) and tumor (n = 6) tissues and quantitative analysis. Significance was calculated with paired Student’s t test. d, e Representative images uncovering TILs and CD8+ T cells infiltration in non-TNBC and TNBC samples with the low and high B7-H3 expression and quantitative analysis. n (samples with low B7-H3 in non-TNBC) = 24, n (samples with high B7-H3 in non-TNBC) = 59, n (samples with low B7-H3 in TNBC) = 24, and n (samples with high B7-H3 in TNBC) = 56. Data presented as mean ± SD. Significance in non-TNBC samples was calculated with Student’s t test, and significance in TNBC samples was calculated with Mann–Whitney test. f Anti-tumor immune infiltration levels in non-TNBC and TNBC samples with the low and high B7-H3 expression in the TCGA cohort.

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