Table 2 Adjusted association with time to CNS failure or death from Landmarks post 1st stereotactic radiosurgery
Patient Characteristics | Hazard Ratio | 95% CI | P-value |
|---|---|---|---|
Landmark 1 | |||
Systemic PD prior to LM1 vs not. | 3.16 | 1.46, 6.83 | 0.0034 |
Age (per decade) | 0.80 | 0.63, 1.01 | 0.0584 |
Race (white vs not white) | 1.00 | 0.43, 2.32 | 0.9898 |
KPS 90–100 vs <90 | 0.49 | 0.27, 0.88 | 0.0186 |
ER + /Her2- vs Her2+ | 1.80 | 0.91, 3.53 | 0.0904 |
ER-/Her2- vs Her2+ | 2.77 | 1.23, 6.25 | 0.0142 |
Brain Mets at SRS1 ( > 1 vs 1) | 2.40 | 1.30, 4.45 | 0.0052 |
PTV (per log) | 0.98 | 0.80, 1.19 | 0.8173 |
Fractions (1 vs 3 or 5) | 0.82 | 0.45, 1.50 | 0.5285 |
Landmark 2 | |||
Systemic PD prior to LM2 vs not. | 5.32 | 2.33, 12.15 | <0.0001 |
Age (per decade) | 0.84 | 0.65, 1.10 | 0.2070 |
Race (white vs not white) | 0.81 | 0.30, 2.20 | 0.6786 |
KPS 90–100 vs <90 | 0.85 | 0.43, 1.67 | 0.6290 |
ER + /Her2- vs Her2+ | 0.82 | 0.37, 1.81 | 0.6236 |
ER-/Her2- vs Her2+ | 1.26 | 0.48, 3.28 | 0.6336 |
Brain Mets at SRS1 ( > 1 vs 1) | 2.18 | 1.05, 4.52 | 0.0367 |
PTV (per log) | 1.05 | 0.83, 1.33 | 0.6932 |
Fractions (1 vs 3 or 5) | 0.72 | 0.35, 1.45 | 0.3514 |
