Fig. 1: Study design and flow diagram.

In the dashed box on the left are three representative patients. For each patient, the total number of Bxs was determined. Bxs were classified as core, surgical or metastatic and were ordered chronologically. Met metastatic, TN triple negative, ER estrogen receptor, PR progesterone receptor, Bxs biopsies, NA neoadjuvant, IHC immunohistochemistry.