Fig. 3: HER2 status discordance between matched Bxs of patients with TNBC.

a HER2 status distribution according to the Bx type and ER status. b HER2 status discordance between core-surgical matched Bxs, early-metastatic matched Bxs and two metastatic matched Bxs. For the early-metastatic matched analysis, the core Bx was considered the early Bx, unless the core Bx was missing and then the surgical bx was used instead. * Significant discordance between matched Bxs. c The impact of neoadjuvant therapy on core-surgical HER2 status discordance. Matched Bxs are repeat biopsies taken from the same patient at specified time points throughout the disease course. d HER2 status discordance between matched core-surgical-metastatic Bxs. Bxs biopsies, ER estrogen receptor, TN triple negative.