Fig. 4: TNBC tumors exhibit greater immunosuppression than non-TNBC tumors. | npj Breast Cancer

Fig. 4: TNBC tumors exhibit greater immunosuppression than non-TNBC tumors.

From: Subtype- and race-specific variations in the immune landscape of breast cancer: therapeutic implications

Fig. 4

A Volcano plot representing the up-regulated (red dots) and down-regulated (blue dots) genes in TNBC compared to the non-TNBC samples. B Heat map representing the expression pattern of the differentially expressed genes among the TNBC and non-TNBC samples. C KEGG pathway analysis of the differentially expressed genes showing up-regulated and down-regulated pathways in TNBC compared to non-TNBC samples. D Representation of selected up-regulated genes associated with immunosuppression (FOXP3, PDCD1, ICOS, LAG3, CTLA4, IDO1) and down-regulated genes associated with immune activation (GATA3, IKBKB) in TNBC compared to non-TNBC samples. The p-value was calculated using the non-parametric Mann-Whitney test. A p-value < 0.05 was considered statistically significant.

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