npj Breast Cancer

Table 5 Concordance rates and agreement between manual and AI-assisted HER2 scoring

From: HER2-low and ultralow expression of invasive breast carcinoma: clinicopathological features and immunohistochemical consistency analysis

Manual A	Manual B							HER2-Non-amplified
	Manual B							Manual A	Manual B
	HER2 0	HER2 1+	HER2 2+	HER2 3+	CR	κ	P	Manual A	HER2 0	HER2 1+	HER2 2+	HER2 3+	CR	κ	P
HER2 0	68	14	0	0	79.43%	0.711	<0.001	HER2 0	68	14	0	0	77.02%	0.61	<0.001
HER2 1+	10	45	2	0				HER2 1+	10	45	1	0
HER2 2+	0	12	21	0				HER2 2+	0	12	11	0
HER2 3+	0	0	5	32				HER2 3+	0	0	0	0
AI-a A	AI-a B							AI-a A	AI-a B
AI-a A	HER2 0	HER2 1+	HER2 2+	HER2 3+	CR	κ	P	AI-a A	HER2 0	HER2 1+	HER2 2+	HER2 3+	CR	κ	P
HER2 0	62	2	0	0	85.17%	0.794	<0.001	HER2 0	62	2	0	0	82.61%	0.713	<0.001
HER2 1+	17	55	2	0				HER2 1+	17	55	2	0
HER2 2+	0	8	23	1				HER2 2+	0	7	16	0
HER2 3+	0	0	1	38				HER2 3+	0	0	0	0

Manual CS	Manual A							HER2-Non-amplified
	Manual A							Manual CS	Manual A
	HER2 0	HER2 1+	HER2 2+	HER2 3+	CR	κ	P	Manual CS	HER2 0	HER2 1+	HER2 2+	HER2 3+	CR	κ	P
HER2 0	70	5	0	0	86.60%	0.813	<0.001	HER2 0	70	5	0	0	85.09%	0.751	<0.001
HER2 1+	12	50	6	0				HER2 1+	12	50	6	0
HER2 2+	0	2	27	3				HER2 2+	0	1	17	0
HER2 3+	0	0	0	34				HER2 3+	0	0	0	0
AI-a CS	AI-a A							AI-a CS	AI-a A
AI-a CS	HER2 0	HER2 1+	HER2 2+	HER2 3+	CR	κ	P	AI-a CS	HER2 0	HER2 1+	HER2 2+	HER2 3+	CR	κ	P
HER2 0	62	7	0	0	91.39%	0.881	<0.001	HER2 0	62	7	0	0	90.06%	0.836	<0.001
HER2 1+	2	65	5	0				HER2 1+	2	65	5	0
HER2 2+	0	2	26	1				HER2 2+	0	2	18	0
HER2 3+	0	0	1	38				HER2 3+	0	0	0	0

Manual CS	Manual B							HER2-Non-amplified
	Manual B							Manual CS	Manual B
	HER2 0	HER2 1+	HER2 2+	HER2 3+	CR	κ	P	Manual CS	HER2 0	HER2 1+	HER2 2+	HER2 3+	CR	κ	P
HER2 0	73	2	0	0	92.82%	0.899	<0.001	HER2 0	73	2	0	0	91.93%	0.861	<0.001
HER2 1+	5	63	0	0				HER2 1+	5	63	0	0
HER2 2+	0	6	26	0				HER2 2+	0	6	12	0
HER2 3+	0	0	2	32				HER2 3+	0	0	0	0
AI-a CS	AI-a B							AI-a CS	AI-a B
AI-a CS	HER2 0	HER2 1+	HER2 2+	HER2 3+	CR	κ	P	AI-a CS	HER2 0	HER2 1+	HER2 2+	HER2 3+	CR	κ	P
HER2 0	69	0	0	0	93.78%	0.913	<0.001	HER2 0	69	0	0	0	92.55%	0.875	<0.001
HER2 1+	10	62	0	0				HER2 1+	10	62	0	0
HER2 2+	0	3	26	0				HER2 2+	0	2	18	0
HER2 3+	0	0	0	39				HER2 3+	0	0	0	0

CR concordance rate, κ Kappa, AI-a AI-assisted.

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