Fig. 2: Growth kinetics and metastatic behavior of 9 mouse TNBC cell line-derived primary tumors. | npj Breast Cancer

Fig. 2: Growth kinetics and metastatic behavior of 9 mouse TNBC cell line-derived primary tumors.

From: Tractable mouse TNBC models capture the heterogeneous tumor immune microenvironment and adaptation to PD-L1 blockade

Fig. 2

a Weekly monitoring of primary tumor growth following orthotopic inoculation of mouse TNBC cell lines in syngeneic mouse mammary glands. b Lung metastases when primary tumors reached their humane endpoint (i.e., 1 cm³ size). c H&E histology of lung metastases in the EMT6-, AT3-, 66CL4-, 4T1-cold-, 4T1-hot- and MVT1-based model. Scale bars = 200 µm. d Weight of the spleen isolated from the mouse TNBC models when primary tumors reached their humane endpoint. The dotted line highlights the mean spleen weight of 4 healthy mice. e H&E histology of the spleen derived from the 4T1-hot- and 4T1-cold-based model, with histology of a healthy spleen for comparison. Scale bars = 200 µm. Data in a, d are presented as the means ± standard error of the mean (SEM). *p < 0.05, **p < 0.01, ***p < 0.001.

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