Fig. 1
From: Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer
Workflow and data set. a Circular RNA expression was analyzed in total RNA from 457 NMIBC samples using a modified version of the find_circ pipeline (see Methods). In total, 38,365 unique circRNAs were identified and characterized. A total of 279 highly expressed circRNAs were analyzed and annotated with their biological features and clinical correlations. A set of circRNA candidates that correlate with bladder cancer progression were identified. b Distribution among stages and grades of the 457 bladder cancer samples. c Illustration of how alternative splicing can generate circular transcripts (left) instead of linear transcripts (right). The positions of reads revealing a backspliced circRNA versus a linearly spliced transcript are shown
