Fig. 6

Mutations in driver candidate miR-122 and their correlation with expression and survival. a The 4 kb genomic region of the MIR122 gene detected as a significant element in the driver screen of the original data set with PhyloP conservation scores, INDELs, and SNVs. Cancer types are color coded in the gray shaded box. b Close up of the miR-122 region with tracks for pre-miRNA, mature miRNA, EvoFold secondary structure prediction, PhyloP conservation scores, and exome mutations from TCGA. Mutations are named by their associated sample ID and colored red if used later in the correlation analysis of expression and survival shown in c and d. c Correlation between miR-122 expression and miR-122 target site motif enrichment in 266 TCGA liver cancer samples. Motif enrichment is based on expression of mRNAs and motif occurrences in their 3′UTRs (see Methods). Samples mutated in the miR-122 region in b are indicated in red. d Survival correlation analysis of TCGA liver mutations in miR-122. The number of mutated samples and non-mutated samples at each time point is indicated below the plot