Table 4 Comparison of age at diagnosis and time to diagnosis between cases (rWGS plus standard tests) and controls (standard tests alone)

From: The NSIGHT1-randomized controlled trial: rapid whole-genome sequencing for accelerated etiologic diagnosis in critically ill infants

 

Original analysisa

Sensitivity analysisb

 

p-value for non-proportional hazards

p-value for a difference in overall diagnostic rates

p-value for non-proportional hazards

p-value for a difference in overall diagnostic rates

Age at diagnosis

0.002

0.043

0.003

0.15

Time to diagnosis from enrollment

0.002

0.040

0.002

0.11

  1. aPeto–Peto test used instead of log-rank test due to evidence of non-proportional hazards
  2. bPeto–Peto test when patients with a partial diagnosis (5004 and 5061) considered undiagnosed.
Back to article page