Fig. 5 | npj Genomic Medicine

Fig. 5

From: Identification of an immune gene expression signature associated with favorable clinical features in Treg-enriched patient tumor samples

Fig. 5

Gene signature analysis in TCGA validation dataset (n = 626). a 32-gene signature expression k-means clustering produces two clusters (ncluster1 = 332, ncluster2 = 294). Clusters derived from 32-gene signature expression in TCGA validation data versus CD8+ T cell activity marker expression for b CD8A, c CD8B, d HLA-A, and e PRF1 (P = 4.19e-79, P = 1.59e-69, P = 2.96e-17, and P = 5.20e-58, respectively; Fig. 4b-e). f CIBERSORT RNA-seq deconvolution results for relative immune cell type abundances between patient tumor samples from k-means clusters (only differentially represented cell types (P < 0.05) were selected for presentation/visualization purposes; see Supp. Table 4 for absolute cell type abundances). g Overall survival plot/Cox proportional hazard regression analysis results between cluster1 patients (red/top line) and cluster2 patients (green/bottom line), P = 0.00018, HR = 0.40[0.49–0.80]

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