Fig. 6 | npj Genomic Medicine

Fig. 6

From: Identification of an immune gene expression signature associated with favorable clinical features in Treg-enriched patient tumor samples

Fig. 6

Patient immunophenoscore and immunotherapy gene set analysis. a Mean Immunophenoscores represented per cluster derived as described in methods (bar whiskers represent standard deviations). Normalized gene expression plots between cluster1 and cluster2 patients for b PD-1 (P < 8.34e-15) and c CTLA-4 (P < 1.83e-3). d K-means clusters produced by each the immunotherapy gene set (19) and our gene set, with both gene sets showing enrichment for chemosensitive tumor samples (P = 0.015, and P = 0.0007, respectively). Concordance table showing similar unsupervised clusters are produced with ‘good’ concordance (Cohen’s kappa = 0.64). e cluster1 patients possessed significantly elevated expression for 12 out of 18 genes identified by the 2CT-CRISPR assay system (acceptable P < 0.003)

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