Fig. 1
The mutational landscape of pNETs. Coding region somatic non-synonymous SNVs/indels, large deletions, and intronic mutations within 2 bp of splice sites with any putative functional significance (see Methods) are shown. Tumors are indicated in columns and genes in rows. Colored squares indicate mutation type, with dots indicating that loss of the remaining wild-type allele (LoH) could be confirmed for the locus through changes in both allele frequency of germline heterozygous SNPs and normalized relative regional sequence depth in tumor vs. normal samples. In some tumors, there were no detectable mutations in the 637 genes covered by the targeted sequencing panel
