Table 2 Significant and replicated DE genes between AAs and EAs (p < 0.05) from a genome-wide discovery of genes associated with West African ancestry (FDR < 0.10)

From: Hepatocyte gene expression and DNA methylation as ancestry-dependent mechanisms in African Americans

Geneb

AA Hepatocyte Cohort

DE in AA vs EAa

 

Effect size

p

FDR < 0.10

p < 0.05c

IL18

3.152

7.25E−05

0.0471

0.00000126

APOL1

−2.848

3.83E−05

0.0380

0.000202

VEGFA

−2.246

4.91E−05

0.0421

0.000502

PARD3

0.437

1.86E−04

0.0773

0.000696

SAP30

−1.945

2.93E−04

0.0788

0.00167

LRRC37A2

−0.306

6.73E−04

0.0988

0.00249

ENO1

−1.007

1.89E−04

0.0773

0.00266

PGK1

−0.929

5.29E−04

0.0882

0.00268

DGCR5

2.192

1.62E−04

0.0751

0.00278

MRO

1.131

2.57E−05

0.0380

0.00282

GREM2

−2.191

6.86E−04

0.0988

0.00327

CYP21A2

−2.986

3.17E−04

0.0790

0.00385

CEBPB

−1.454

6.36E−04

0.0967

0.00445

MAD2L1BP

−0.505

3.04E−04

0.0790

0.00605

GPR4

−1.316

3.08E−04

0.0790

0.00706

RNF149

−0.833

2.37E−04

0.0788

0.00743

GPI

−1.453

4.58E−05

0.0411

0.0123

SLC22A15

−1.271

6.86E−04

0.0988

0.0125

HIC1

−1.567

9.64E−06

0.0307

0.013

APOL2

−1.643

1.06E−04

0.0583

0.0134

MME

2.640

3.94E−04

0.0854

0.0137

MKNK2

−1.545

3.44E−04

0.0811

0.0262

MGRN1

−1.010

2.76E−04

0.0788

0.0313

C3orf33

0.506

6.45E−04

0.0973

0.0314

PTPN4

0.484

5.37E−04

0.0882

0.0321

NPR2

1.235

6.11E−05

0.0471

0.0444

MSX1

1.432

2.90E−04

0.0788

0.0448

PDK1

−2.038

6.30E−04

0.0966

0.0498

  1. aReplication in differentially expressed (DE) genes between 23 African Americans (AAs) and 183 European Americans (EAs)
  2. bGenes with FDR < 0.1 in the Replication Cohort are shown in bold
  3. cReplication p value (p < 0.05) based on 131 discovery genes (Supplemental Data S1)
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