Fig. 2: Breast cancer risk loci with strong predictions for allelic-differential binding of miRNA.

a BC risk locus 19p13.11 with candidate target gene ABHD8 and b BC risk locus 1q21.1 with candidate target gene RNF115. Both figures display a top panel with the genomic organisation of RefSeq genes (NCBI Release 109), with the candidate target genes in red and displaying the transcript predicted to have differential binding of miRNAs. The middle panel displays the genomic organisation of the tested raSNPs (GWAS-significant variants in green, plus proxy SNPs in high LD in black) in each locus, identified and tested in this study. raSNPs located in the 3′-UTR of candidate target genes with the strongest predictions for allelic-differential binding of miRNAs (rSNP candidates) are indicated in cyan. raSNPs in red have weaker predictions for allelic-differential binding of miRNAs. The third panel shows the DAE data for heterozygous individuals tested for the SNP indicated immediately below. The alleles are indicated for each SNP in the order of the AE ratio calculated (i.e. A/G corresponds to the ratio of allele A by allele G). Dashed horizontal lines indicate the threshold for DAE set at 1.5-fold difference between alleles (\(| {\mathrm{log}}_2\,{\mathrm{AE}}\,{\mathrm{ratio}}| = 0.58\)).