Table 1 Previously functionally validated SNPs affecting miRNA binding evaluated by TargetScan and miRanda.
From: Allele-specific miRNA-binding analysis identifies candidate target genes for breast cancer risk
SNP | Locus | Gene | Transcripta | miRNAb | Allelesc | Ref. allele | Alt. allele | Associated disease | ||
|---|---|---|---|---|---|---|---|---|---|---|
Context ++d | MFEe | Context ++d | MFEe | |||||||
rs4245739[f21 | 1q32 | MDM4 | ENST00000367182.3 | hsa-miR-191-5p | A/C | — | — | −0.309 | — | Ovarian cancer |
rs793013 | 1q42.3 | TOMM20 | ENST00000366607.4 | hsa-miR-4273-5p | A/G | −0.151 | — | — | — | Colorectal cancer |
rs3559256722 | 3q28 | TP63 | ENST00000264731.3 | hsa-miR-140-5p | C/T | −0.234 | — | — | — | Bladder cancer |
rs107173816 | 4q32.3 | PALLD | ENST00000261509.6 | hsa-miR-96-5p | G/C | — | — | −0.12 | — | Breast cancer |
hsa-miR-182-5p | — | — | −0.298 | — | ||||||
ENST00000335742.7 | hsa-miR-96-5p | — | — | −0.126 | — | |||||
hsa-miR-182-5p | — | — | −0.317 | — | ||||||
rs1272020823 | 8p22 | FGF20 | ENST00000180166.5 | hsa-miR-433-3p | G/A | −0.201 | — | — | — | Parkinson’s disease |
rs422524 | 11q23.3 | APOC3 | ENST00000227667.3 | hsa-miR-4271 | G/T | — | −16.69 | −0.172 | −21.07 | Coronary heart disease |
rs11540855f20 | 19p13.11 | ABDH8 | ENST00000247706.3 | hsa-miR-4707-3p | A/G | — | −23.93 | −0.225 | −25.95 | — |
