Table 2 Newly identified 5th, 6th and 7th degree-related pairs.

From: Identity by descent analysis identifies founder events and links SOD1 familial and sporadic ALS cases

FIDa 1

IIDb 1

FIDa 2

IIDb 2

Estimated degree

IID 1 mutation

IID 2 mutation

18

18-60

35

35-142

5

p.V149G

p.V149G

18

18-58

35

35-142

5

p.V149G

p.V149G

197

197-060095

mq36

mq36-MQ160147

5

p.I114T

p.I114T

18

18-77

35

35-142

6

p.V149G

p.V149G

18

18-67

35

35-142

6

p.V149G

p.V149G

18

18-77

197

197-060228

6

p.V149G

p.I114T

334

334-060820

374

374-140839

6

p.I114T

p.I114T

334

334-120512

374

374-140839

6

p.I114T

p.I114T

334

334-060820

374

374-140975

6

p.I114T

p.I114T

334

334-120512

374

374-140975

6

p.I114T

p.I114T

123

123-971530

259

259-080285

6

p.I114T

p.I114T

197

197-060228

mq36

mq36-MQ160147

6

p.I114T

p.I114T

SALS

MN201517c

SALS

SALS2258c

6

p.I114T

p.I114T

76

76-940290

SALS

MN201517

7

p.I114T

p.I114T

76

76-940290

SALS

SALS2258

7

p.I114T

p.I114T

267

267-090221

286

286-090750

7

p.I114T

p.I114T

18

18-41

35

35-142

7

p.V149G

p.V149G

197

197-060095

43

43-070626

7

p.I114T

p.I114T

197

197-060095

43

43-080797

7

p.I114T

p.I114T

197

197-060228

43

43-080797

7

p.I114T

p.I114T

  1. aFamily or sporadic ID.
  2. bIndividual ID.
  3. cTwo sporadic cases were inferred as close relatives (MN201517 and SALS2258). The third sporadic case was inferred as an 8th degree relative or high with other SOD1 p.I114T carries, thus is not present in this table.
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