Fig. 2: Applying an Effectiveness-Implementation Hybrid study design11 to evaluate clinical and implementation aims.
From: Learning from scaling up ultra-rapid genomic testing for critically ill children to a national level
This timeline demonstrates the use of the Consolidated Framework for Implementation Research (CFIR) and the hybrid effectiveness/implementation model as the programme progresses. Initially, as a hybrid 1 effectiveness/implementation model, the single state trial in 2016-7 placed priority on producing evidence on clinical effectiveness. As clinical effectiveness evidence developed, the multistate trial (the focus of this paper) in 2018-9 ran as a hybrid model 2, with equal focus on generating implementation and clinical effectiveness evidence. Future programmes will be hybrid model 3 with attention on creating evidence to support implementation.
