Fig. 4: Maximum AUC given by the different methods used to calculate MPS, when classifying from the Australian (Ncases = 613, Ncontrols = 782) to the Netherlands (Ncases = 1159 and Ncontrols = 637) ALS cohort. | npj Genomic Medicine

Fig. 4: Maximum AUC given by the different methods used to calculate MPS, when classifying from the Australian (Ncases = 613, Ncontrols = 782) to the Netherlands (Ncases = 1159 and Ncontrols = 637) ALS cohort.

From: Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis

Fig. 4

Bars indicate 95% confidence intervals of AUC values for each method. MOA: CI95% = [0.57–0.63]; BLUP: CI95% = [0.58–0.63]; MOMENT: CI95% = [0.62–0.68]; predicted cell proportions (CTP): CI95% = [0.63–0.69]; MOMENT + CTP: CI95% = [0.65–0.7]; and BLUP + CTP: CI95% = [0.66–0.71]. Dashed line indicates AUC = 0.5, i.e., random classification. P values are from logistic regression models. m = number of DNAm probes used to calculate the MPS.

Back to article page