Fig. 6: Analysis combining pharmacogenomic perturbation database screens of multiple drugs that have the potential to promote inflamed or noninflamed immunophenotypic switching. | npj Genomic Medicine

Fig. 6: Analysis combining pharmacogenomic perturbation database screens of multiple drugs that have the potential to promote inflamed or noninflamed immunophenotypic switching.

From: Multiomics characteristics of neurogenesis-related gene are dysregulated in tumor immune microenvironment

Fig. 6

a The schematic plot shows the workflow for identifying potential drugs that can shape the tumor microenvironment. b The dot plots show potential adjuvant drugs that may contribute to favorable immunophenotype transformation. Red: drugs that may induce systematic transcriptomic alternation from a noninflamed TME to an inflamed TME. Blue: opposite drugs. Connectivity is a score calculated by the PharmacoGx package based on the CMAP algorithm, and it represents the drug’s potential to convert the transcriptomic characteristics of “cold” tumors into “hot” tumors.

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