Fig. 8: Mechanism graph of the regulatory network and oncogenic function of KLF5 in gastric cancer. | npj Genomic Medicine

Fig. 8: Mechanism graph of the regulatory network and oncogenic function of KLF5 in gastric cancer.

From: KLF5 activates lncRNA DANCR and inhibits cancer cell autophagy accelerating gastric cancer progression

Fig. 8

KLF5 activates the transcription of DANCR in the promoter region and elevates DANCR expression. DANCR acts as a miR-194 sponge to repress its expression. MiR-194 targets and inhibits AKT2 expression. Therefore, KLF5 promotes the malignant phenotypes of gastric cancer through activation of lncRNA DANCR and impairs miR-194-dependent AKT2 inhibition.

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