Table 1 Urinary exosomal miRNAs differentially expressed between metastatic and localized PCa.

From: Urinary exosome microRNA signatures as a noninvasive prognostic biomarker for prostate cancer

 

Discovery set

Validation set (qRT-PCR)

Combined: model construction set (qRT-PCR)

Discovery (TLDA)

Technical validation (qRT-PCR)

miRNA

Fold change

p-value

Fold change

p-value

Fold change

p-value

Fold change

p-value

miR-636

0.33

0.039

0.82

0.582

0.44

0.013

0.53

0.004

miR-140-3p

2.17

0.017

2.62

0.005

1.76

0.137

1.19

0.424

miR-21

3.15

0.005

2.95

0.003

2.56

0.044

2.20

0.006

miR-16

2.92

0.050

3.31

0.006

1.98

0.190

2.12

0.010

miR-142-3p

4.33

0.002

11.7

7.92 × 10−6

4.83

0.206

3.20

0.021

miR-451

3.88

0.049

8.42

0.003

3.84

0.008

6.31

2.12 × 10−6

  1. Statistically significant differences (P < 0.05) are in bold.
  2. Discovery set: 42 PCa patients (19 localized and 23 metastatic).
  3. Validation set: 70 PCa patients (56 localized and 14 metastatic).
  4. Model construction set (Combined/qRT-PCR): 112 PCa patients (75 localized and 37 metastatic).
  5. TLDA TaqMan low-density miRNA array, qRT-PCR quantitative reverse transcription–polymerase chain reaction.
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