Table 2 Logistic regression results for clinical variables and five miRNAs with PCa metastasis.

From: Urinary exosome microRNA signatures as a noninvasive prognostic biomarker for prostate cancer

 

Univariate

Multivariatea

Variable

OR (95% CI)

P-value

aOR (95% CI)

P-value

Age

1.06 (1.00–1.12)

0.067

  

BMI

1.09 (0.95–1.26)

0.230

  

Preoperative PSA

1.04 (1.02–1.06)

4.63 × 10−4

1.03 (1.01–1.05)

0.004

Prostate volume

1.02 (0.99–1.05)

0.118

  

PSA densityb

3.59 (1.58–8.12)

0.002

  

Clinical Gleason scoreb

 

0.004

  

 7 (3 + 4) vs ≤6

14.7 (1.45–148.0)

0.023

  

 7 (4 + 3) vs ≤6

22.0 (2.58–187.8)

0.005

  

 ≥8 vs ≤6

40.3 (5.02–324.4)

5.09 × 10−4

  

miR-636

0.65 (0.48–0.88)

0.005

0.37 (0.23–0.61)

9.92 × 10−5

miR-21

1.31 (1.07–1.61)

0.009

1.65 (1.17–2.31)

0.004

miR-16

1.34 (1.07–1.66)

0.010

  

miR-142-3p

1.12 (1.01–1.24)

0.035

  

miR-451

1.42 (1.20–1.68)

5.13 × 10−5

1.48 (1.15–1.90)

0.002

  1. 112 PCa cases (75 localized and 37 metastatic) were used for analysis.
  2. OR odds ratio, CI confidence interval, aOR adjusted odds ratio.
  3. aMultivariate analysis was performed by logistic regression analysis with backward selection for preoperative PSA, miR-636, miR-21, miR-16, miR-142-3p, and miR-451.
  4. bPSA density and clinical Gleason score were excluded for multivariate analysis.
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