Table 3 Results of Cox regression analysis of factors associated with BCR-free survival.

From: Urinary exosome microRNA signatures as a noninvasive prognostic biomarker for prostate cancer

 

Univariate

Multivariatea

Variable

HR (95% CI)

P-value

HR (95% CI)

P-value

PCa-MRS

    

 High vs low score

4.23 (2.58–6.96)

1.25 × 10−8

2.26 (1.29–3.96)

0.004

Age

1.02 (0.98–1.06)

0.305

  

BMI

1.05 (0.97–1.15)

0.246

  

Prostate volume

1.00 (0.99–1.02)

0.736

  

Preoperative PSA

1.02 (1.01–1.03)

2.49 × 10−8

1.01 (1.00–1.02)

0.014

PSA density

1.75 (1.40–2.19)

7.59 × 10−7

  

Clinical Gleason score

 

4.43 × 10−6

 

1.74 × 10−4

 7(3 + 4) vs ≤6

7.58 (1.47–39.1)

0.015

7.29 (1.41–37.7)

0.018

 7(4 + 3) vs ≤6

16.9 (3.96–72.1)

1.34 × 10−4

12.6 (2.92–54.2)

0.001

 ≥8 vs ≤6

28.8 (6.90–120.1)

3.99 × 10−6

20.4 (4.80–86.4)

4.33 × 10−5

  1. aMultivariate analysis was performed by Cox regression analysis with backward selection using PCa-MRS (categorical), preoperative PSA, and clinical Gleason score (categorical). To avoid the collinearity effect, PSA density was excluded from the multivariate analysis.
Back to article page