Fig. 1: Subtypes of cutaneous squamous cell carcinoma.

Each vertical bar corresponds to a single tumor. Top track: The mutation burden (mutations per megabase) of each tumor. Middle track: The fraction of mutations within each tumor matching the canonical UV radiation signature. Bottom track: The fraction of mutations attributable to established mutational signatures within each tumor. The proposed etiology of select signatures is indicated. XP = tumors from patients with xeroderma pigmentosum, Sporadic = tumors from patients with no known comorbidities, immunosuppressed: tumors from immunosuppressed patients—this group is further stratified by the usage or absence of azathioprine as an immunosuppressive drug, RDEB = tumors from patients with recessive dystrophic epidermolysis bullosa.