Table 5 Summary of mediation analyses.

From: Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients

Mediator

Indirect effect

p

Direct effect

p

HADS: Depression

3% (0% to 6%)

0.065

9% (−4% to 23%)

0.186

MICRA: Positive

7% (3% to 12%)

<0.001

4% (−9% to 18%)

0.559

Emotions

Happy

8% (1% to 16%)

<0.001

4% (−12% to 19%)

0.640

Empowered

10% (4% to 17%)

<0.001

1% (−13% to 16%)

0.782

Relieved

10% (3% to 17%)

<0.001

2% (−13% to 17%)

0.753

  1. Analyses examined whether the impact of randomization to GS on health behavior changes reported at 6 months were mediated by psychological responses at 6 weeks. Indirect effects are the differences between the GS and control arms in the likelihood of reporting a health behavior change that could be attributed to the impact of GS on potential mediators. Direct effects are the differences between the GS and control arm in the likelihood of reporting a health behavior change after controlling for the potential mediators.
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