Fig. 1: 3′-UTR post-transcriptional impaired SNVs (3′-UTR piSNVs) identified in PCAWG project and ESCC cohorts. | npj Genomic Medicine

Fig. 1: 3′-UTR post-transcriptional impaired SNVs (3′-UTR piSNVs) identified in PCAWG project and ESCC cohorts.

From: Comprehensive characterization of posttranscriptional impairment-related 3′-UTR mutations in 2413 whole genomes of cancer patients

Fig. 1: 3′-UTR post-transcriptional impaired SNVs (3′-UTR piSNVs) identified in PCAWG project and ESCC cohorts.The alternative text for this image may have been generated using AI.

a General workflow for identifying 3′-UTR post-transcriptional impaired SNVs. b Genome-wide gene density distribution of identified piSNVs (blue lines in chromosome body) and 3′-UTR piSNVs (orange peaks) in each chromosome. c Compared to controls in the DSMNC database, the proportion of somatic 3′-UTR piSNVs was significantly elevated in the PCAWG project and ESCC cohorts (*P < 0.05, **P < 0.01, ***P < 0.001). We calculated the ratio of piSNV to SNV in 3′-UTR for each sample, and used wilcoxon rank-sum test to evaluate the distribution differences of 3′-UTR piSNV ratio between cancer samples in each cancer type and control samples. Boxplots elements represent: center line = median, upper and lower hinges = 25 and 75% percentiles, upper and lower whisker = mean ± 1.5*IQR.

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