Fig. 6: Systematic functional effect of 3′-UTR piSNV genes. | npj Genomic Medicine

Fig. 6: Systematic functional effect of 3′-UTR piSNV genes.

From: Comprehensive characterization of posttranscriptional impairment-related 3′-UTR mutations in 2413 whole genomes of cancer patients

Fig. 6: Systematic functional effect of 3′-UTR piSNV genes.The alternative text for this image may have been generated using AI.

GO (a) and KEGG (b) functional enrichment of 2930 3′-UTR piSNV genes; the significant pathological networks (c) and pathways (d, pink: 3′-UTR piSNVs; green: damaging mutations; orchid: 3’-UTR piSNVs and damaging mutations; pink and green: 3′-UTR piSNVs or damaging mutations) of 3′-UTR piSNV genes were performed by Hotnet2 and activePathway workflow, respectively. The major signaling pathways (PI3K/AKT/FGFR/MAPK signaling, EGFR-related signaling, AMPA-related signaling, Notch signaling, and Wnt signaling pathways) were pointed out by light yellow circular backgrounds (d). e Potential clinical drugs identified by CMAP.

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