Fig. 4: Rhodopsin localization to the photoreceptor cell body in the ush2ap.(Cys771Phe) zebrafish. | npj Genomic Medicine

Fig. 4: Rhodopsin localization to the photoreceptor cell body in the ush2ap.(Cys771Phe) zebrafish.

From: Scrutinizing pathogenicity of the USH2A c.2276 G > T; p.(Cys759Phe) variant

Fig. 4: Rhodopsin localization to the photoreceptor cell body in the ush2ap.(Cys771Phe) zebrafish.The alternative text for this image may have been generated using AI.

a Rhodopsin (green signal) localizes to the rod photoreceptor outer segments in wildtype larval eyes. A visual representation of a photoreceptor is shown on the right. b Aberrant localization of rhodopsin to the photoreceptor cell body was observed in ush2ap.(Cys771Phe) larvae (indicated by white arrows), which was observed in a significantly higher number of photoreceptors of ush2ap.(Cys771Phe) larvae as compared to wildtype larvae (c; unpaired t test). Nuclei are stained with DAPI (blue signal). Scale bar: 10 µM. ****p < 0.0001.

Back to article page