Fig. 3: The relationship between hexanucleotide quasi-tandem repeat (QTR) length and residual age at onset of HD.
From: Huntington’s disease age at motor onset is modified by the tandem hexamer repeat in TCERG1
a–c Histograms showing distribution of the sum of two QTR repeat lengths Nsum = Nmin + Nmax for the groups with early (red, R < −Rthr) and late (blue, R > Rthr) onsets. Panels (a, b, and c) correspond to the residual age at onset threshold Rthr of 0, 13, and 20 years, respectively. d Association of the sum of two QTR repeat lengths Nsum with the residual age at onset for the entire HD cohort. Red pluses indicate mean residual age at onset for every sum of QTR repeat lengths. Grey and black dashed lines are plotted using coefficients of the linear regression analysis and regression with selection.
