Fig. 4: Comparison of carrier frequencies among different cohorts.

a Comparison between gnomAD populations and SG10K subpopulations, ChinaMAP Chinese or WBBC Chinese. Spearman’s rank correlation coefficient and Pearson correlation coefficient R scores are illustrated in each cell and color coded. Red indicates high correlation, while blue indicates low correlation. b Comparison between SG10K subpopulations and ChinaMAP Chinese or WBBC Chinese. c Comparison between ChinaMAP Chinese and WBBC Chinese. See also Supplementary Fig. 4 for comparison scatter plots and corresponding statistical P values. d Spearman’s correlation coefficients generated between our calculated carrier frequencies of gnomAD populations and actual ethnicity specific carrier frequencies recorded from NGS based ECS (Taber et al. 2022 study, ref. ⁶). AFR African or African-American, ASJ Ashkenazi Jewish, MWH Mixed or Other White, FCA French Canadian or Cajun, EAS East Asian, FIN Finnish, AMR Hispanic (corresponding to the Latino/Admixed American population in gnomAD), MEA Middle Eastern, NEU Northern European, SAS South Asian, SEA Southeast Asian, SEU Southern European. The color stands for row-wise Z score scaled Spearman’s correlation coefficient. See also Supplementary Fig. 5 for Pearson correlation coefficients.