Fig. 7: Model of chromatin regulators that mediate TBX1 function. | npj Genomic Medicine

Fig. 7: Model of chromatin regulators that mediate TBX1 function.

From: Chromatin regulators in the TBX1 network confer risk for conotruncal heart defects in 22q11.2DS

Fig. 7: Model of chromatin regulators that mediate TBX1 function.The alternative text for this image may have been generated using AI.

Protein complexes involved in histone modifications (NuA4 histone acetyltransferase complex-NuA4 acetyl; Monocyte leukemia zinc finger complex-MOZ; BRG1/BRM complex (SWI/SNF), BAF; Polycomb repressive complex, PRC; Complex of proteins associated with Set1, COMPASS) are shown (similar colors as Fig. 5a-STRING image) surrounding a representative nucleosome. a MYST family proteins involved in histone acetylation with respect to regulation of TBX1 expression. b TBX1 protein regulates expression of downstream genes including WNT5a, via chromatin regulators that belong to several classes as indicated. This is mediated in part, by physical interaction with CHD7. DNA is shown as a gray double helix. Gene activation is shown as an arrow and repression as a cross bar.

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