Fig. 1: Visualization of the mutations reported in ClinVar and utilized in our analysis, displayed based on mismatch type and molecular consequences.
From: DNA and RNA base editors can correct the majority of pathogenic single nucleotide variants
a The 98,513 pathogenic SNVs located in genes. This set was utilized in our analysis of DNA base-editing. b The 18,873 pathogenic SNVs located in genes’ non-coding regions. This subset was utilized in our analysis of RNA base-editing in non-coding regions. c The 79,640 pathogenic SNVs located in genes’ coding regions, out of which 78,835 were annotated by the RNA sequence reference. This subset of 78,835 SNVs was employed in our analysis of RNA base editing within coding regions and in the assessment of amino acid improvements.
