Fig. 1: Overall and regional association results.
From: Pharmacogenomics of coronary artery response to intravenous gamma globulin in kawasaki disease
a Manhattan Plot displaying Whole Genome Sequence Association results with—Large (medium/giant) Coronary Aneurysm (N = 92) vs no Coronary Artery Aneurysm (N = 276). Negative log10-transformed P values from the logistic regression model (additive model) are plotted on the y-axis and the SNP genomic locations on the x-axis (colors representing different autosomal chromosomes). Locus Zoom plots for selected gene regions in (b) Chromosome 7 with rs10276547 the most significant SNP in the region, (c) chromosome 8 with rs9643846 the most significant SNP in the region, (d) Chromosome 9 with rs600075 the most significant SNP in the region. Vertical axis (on the left) is the –log10 of the p-value, the horizontal axis is the chromosomal position. Each dot represents a SNP tested for association with large coronary aneurysm. Linkage disequilibrium between the most significant SNP, listed at the top of each plot, and the other SNPs in the plot is shown by the r2 legend in each plot. Vertical axis (on the right) is the recombination—the site and rate are represented by red curves.
