Table 2 Top genes associated with large (medium/giant) coronary aneurysm (CCA/L) (z ≥ 5), persistent CCA/L (P-CCA/L), any coronary artery aneurysm (CAA) (z ≥ 2.5), and persistent CAA (P-CAA)
From: Pharmacogenomics of coronary artery response to intravenous gamma globulin in kawasaki disease
Overall Top 10 Hits | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Genes and gene regions | Large Aneurysm | Persistent Large Aneurysm | Any Aneurysm | Persistent Any Aneurysm | |||||
SNP* | Closest gene | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value |
rs62154092 (T/c) | ACTR3BP2;NONE | 0.17 [0.09, 0.33] | 6.32E–08 | 0.16, [0.08, 0.30] | 3.22E–08 | 0.23, [0.14, 0.39] | 3.25E–08 | 0.20, [0.12, 0.36] | 3.28E–08 |
rs1424006606 (C/t) | FRG1DP;FRG2EP | 0.15 [0.08, 0.31] | 1.71E–07 | 0.19, [0.09, 0.38] | 3.37E–06 | 0.40, [0.26, 0.59] | 6.78E–06 | 0.29, [0.18, 0.48] | 1.53E–06 |
rs28730284 (G/a) | KLRC2 | 0.18 [0.10, 0.35] | 2.20E–07 | 0.20, [0.10, 0.39] | 1.96E–06 | 0.37, [0.25, 0.55] | 6.34E–07 | 0.35, [0.22, 0.55] | 6.86E–06 |
rs1396081550 (C/t) | FAM242B;MIR4477A | 0.24 [0.14, 0.41] | 2.28E–07 | 0.22, [0.13, 0.39] | 1.97E–07 | 0.35, [0.24, 0.52] | 3.01E–07 | 0.35, [0.22, 0.54] | 4.14E–06 |
rs62330192 (A/g) | SFRP2;DCHS2 | 0.19 [0.10, 0.36] | 2.59E–07 | 0.20, [0.10, 0.38] | 1.09E–06 | 0.38, [0.25, 0.56] | 1.14E–06 | 0.31, [0.19, 0.49] | 7.82E–07 |
rs1258107032 (T/a) | FRG1CP;FRG1DP | 5.76 [2.93, 11.32] | 3.83E–07 | 6.11, [2.96, 12.63] | 1.04E–06 | 2.70, [1.82, 4.00] | 7.60E–07 | 3.44, [2.13, 5.57] | 4.80E–07 |
rs1379390981 (T/g) | FAM242B;MIR4477A | 0.21 [0.11, 0.38] | 3.86E–07 | 0.20, [0.11, 0.38] | 8.74E–07 | 0.27, [0.17, 0.44] | 6.23E–08 | 0.24, [0.14, 0.41] | 1.93E–07 |
rs1424309393 (A/t) | FRG1CP;FRG1DP | 5.64 [2.87, 11.08] | 5.37E–07 | 5.97, [2.88, 12.34] | 1.45E–06 | 2.74, [1.84, 4.07] | 6.02E–07 | 3.41, [2.11, 5.53] | 5.86E–07 |
rs9643846 (G/t) | ZMAT4 | 4.12 [2.36, 7.20] | 6.57E–07 | 4.16, [2.35, 7.39] | 1.10E–06 | 2.30, [1.54, 3.44] | 5.33E–05 | 2.04, [1.30, 3.20] | 1.97E–03 |
rs377109159 (T/c) | MIR4445;NECTIN3-AS1 | 4.60 [2.52, 8.40] | 6.86E–07 | 5.24, [2.80, 9.80] | 2.23E–07 | 2.83, [1.79, 4.47] | 8.01E–06 | 3.49, [2.11, 5.79] | 1.25E–06 |
Top 5 exonic SNPs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
SNP | Gene | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value |
rs11259953 (A/c) | WHAMM | 3.30(1.90, 5.74) | 2.25E–05 | 3.34(1.88, 5.93) | 3.74E–05 | 1.98(1.29, 3.02) | 1.65E–03 | 2.01(1.24, 3.24) | 4.33E–03 |
rs11259954 (C/g) | WHAMM | 3.30(1.9, 5.74) | 2.25E–05 | 3.34(1.88, 5.93) | 3.74E–05 | 1.98(1.29, 3.02) | 1.65E–03 | 2.01(1.24, 3.24) | 4.33E–03 |
rs1055510 (A/g) | MADD-AS1 | 0.42(0.27, 0.65) | 8.76E–05 | 0.36(0.23, 0.58) | 2.16E–05 | 0.59(0.43, 0.79) | 4.24E–04 | 0.51(0.36, 0.72) | 1.13E–04 |
rs1052373 (C/t) | MYBPC3 | 0.44(0.29, 0.68) | 1.85E–04 | 0.39(0.25, 0.61) | 5.28E–05 | 0.60(0.45, 0.81) | 7.69E–04 | 0.53(0.37, 0.74) | 2.18E–04 |
rs77868901 (G/c) | TMEM259 | 9.00(2.76, 29.31) | 2.66E–04 | 8.57(2.62, 28.05) | 3.86E–04 | 3.60(1.21, 10.71) | 2.13E–02 | 4.69(1.51, 14.54) | 7.46E–03 |
Top 10 non-exonic SNPs in the gene | |||||||||
|---|---|---|---|---|---|---|---|---|---|
SNP | Gene | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value |
rs28730284 (A/g) | Upstream KLRC2 | 0.18(0.10, 0.35) | 2.20E–07 | 0.20(0.1, 0.39) | 1.96E–06 | 0.37(0.25, 0.55) | 6.34E–07 | 0.35(0.22, 0.55) | 6.86E–06 |
rs9643846 (T/g) | Intronic ZMAT4 | 4.12(2.36, 7.2) | 6.57E–07 | 4.16(2.35, 7.39) | 1.10E–06 | 2.3(1.54, 3.44) | 5.33E–05 | 2.04(1.3, 3.2) | 1.97E–03 |
rs9643847 (G/a) | Intronic ZMAT4 | 3.95(2.27, 6.86) | 1.14E–06 | 3.86(2.19, 6.82) | 3.19E–06 | 2.14(1.44, 3.2) | 1.89E–04 | 1.99(1.27, 3.12) | 2.62E–03 |
rs57504215 (G/a) | Intronic ZMAT4 | 3.88(2.23, 6.78) | 1.78E–06 | 3.90(2.2, 6.92) | 3.04E–06 | 2.18(1.45, 3.27) | 1.61E–04 | 1.9(1.21, 2.98) | 5.60E–03 |
rs60545202 (A/g) | Intronic ZMAT4 | 3.91(2.23, 6.84) | 1.82E–06 | 3.96(2.22, 7.06) | 2.97E–06 | 2.13(1.41, 3.23) | 3.47E–04 | 1.98(1.26, 3.14) | 3.37E–03 |
rs59556769 (G/a) | Intronic ZMAT4 | 3.73(2.16, 6.42) | 2.11E–06 | 3.87(2.21, 6.77) | 2.18E–06 | 2.01(1.35, 2.99) | 6.39E–04 | 1.98(1.27, 3.08) | 2.67E–03 |
rs10276547 (C/t) | ncRNA intronic LOC100128317 | 5.55(2.73, 11.27) | 2.17E–06 | 5.93(2.88, 12.2) | 1.34E–06 | 2.74(1.56, 4.81) | 4.31E–04 | 3.88(2.09, 7.22) | 1.78E–05 |
rs73677451 (G/t) | Intronic ZMAT4 | 3.70(2.15, 6.38) | 2.36E–06 | 3.72(2.13, 6.52) | 4.14E–06 | 2.08(1.39, 3.09) | 3.34E–04 | 1.98(1.27, 3.09) | 2.50E–03 |
rs600075 (G/a) | Intronic PTPRD | 3.59(2.11, 6.09) | 2.36E–06 | 3.55(2.05, 6.16) | 6.45E–06 | 2.30(1.57, 3.37) | 1.79E–05 | 2.41(1.56, 3.74) | 8.24E–05 |
rs5896385 (-/a) | Intronic PTPRD | 3.59(2.11, 6.09) | 2.36E–06 | 3.55(2.05, 6.16) | 6.45E–06 | 2.30(1.57, 3.37) | 1.79E–05 | 2.41(1.56, 3.74) | 8.24E–05 |
