Fig. 2: Genetic admixture in Caribbean Hispanics.
A Density plots of the study cohort with green representing Native American (AMR: 103 Native Mesoamerican and South American individuals from the Human Genome Diversity Project/ Centre d’Etude du Polymorphism database (HGDP-CEPH); representing Maya and Pima in Mexico, Colombian in Colombia, Karitiana and Surui in Brazil), purple representing African (YRI: 61 Yoruba in Ibadan, Nigeria from 1KGP), and cyan representing European (IBS: 107 Iberian populations in Spain from 1KGP) ancestries, respectively42,43. There are different proportions of African and European contributions to the overall genetic background of each participant. Native American curve suggests this ancestral component is less variable among participants, but also smaller in terms of global proportion. B The individual proportions of the three parental components in the study cohort (ancestral fractions). Each column represents an individual in the study cohort. C Principal component analysis (PCA) in each participant of the study (PR: Caribbean Hispanics from Puerto Rico, in red color) along with the European (IBS), African (YRI), and Native American (AMR) reference populations. D Bar chart of the average ancestral proportions across the cohort. When merged with non-overlapping SNPs typed previously in all individuals from our study cohort (PR), the resulting data for admixture analysis at both the population and regional (continental) level consist of over 30 million SNPs.
