Table 1 SNPs of genome-wide significant association with spherical equivalent in children

From: Genome-wide association study identified novel loci and gene-environment interaction for refractive error in children

Chr

SNP

Nearest gene

 

Discovery phase

Replication phase

EAa

HKCES-1 (N = 864)

LAMP (N = 373)

Meta-GWAS (N = 1237)

HKCES-2 (N = 2066)

SMS (N = 2027)

All cohorts (N = 5330)

EAF

β

P

EAF

β

P

β

P

EAF

β

P

EAF

β

P

β

P

Q testb

4

rs292034

MIR4275

G

0.013

-1.47

6.62 × 10−7

0.011

-1.34

3.69 × 10−2

-1.45

5.72 × 10−8

0.011

-0.63

1.40 × 10−3

0.013

-0.54

0.031

-0.81

1.42 × 10−9

0.05

4

rs17074027

TENM3

G

0.058

-0.63

7.66 × 10−6

0.06

-0.49

7.89 × 10−2

-0.60

1.46 × 10−6

0.076

-0.31

6.62 × 10−5

0.073

-0.30

6.20 × 10−3

-0.36

8.41 × 10−11

0.19

6

rs6925312

LOC101928911

G

0.77

-0.32

1.42 × 10−5

0.75

-0.33

0.039

-0.32

1.41 × 10−6

0.78

-0.16

4.03 × 10−4

0.79

-0.19

0.01

-0.21

5.50 × 10−10

0.27

8

rs4609227

FAM135B

C

0.025

-1.02

2.53 × 10−7

0.025

-0.96

2.35×10−2

-1.01

1.40 × 10−8

0.025

-0.63

2.37 × 10−7

0.037

-0.02

0.91

-0.50

9.44 × 10−10

0.025

  1. Chr chromosome, SNP single nucleotide polymorphism, BP base pair position, EA effect allele, EAF effect allele frequency.
  2. aEA refers to the allele negatively associated with spherical equivalent.
  3. bQ test is used for heterogeneity test, Q < 0.01 indicates statistically significant heterogeneities.
Back to article page