Table 2 Differentially expressed genes between subjects with normal-to-mildly elevated ICP and with ICP higher than 18 mmHg

miRNA

U value

p value

Ratio (higher ICP/lower ICP)

Fold change (log2 ratio)

dme-miR-7

80

0.007

29.53

4.88

hsa-miR-938

78.5

0.009

48.11

5.59

hsa-miR-143

76.5

0.013

579.88

9.18

hsa-let-7i

77

0.013

16.73

4.06

hsa-miR-618

14.5

0.014

0.009

−6.80

hsa-miR-374

76

0.015

78.96

6.30

hsa-miR-657

15

0.017

0.07

−3.84

hsa-miR-190b

15

0.017

0.003

−8.38

hsa-miR-10b

16

0.021

0.18

−2.47

hsa-miR-589

74

0.025

16.38

4.03

hsa-miR-16-1

74

0.026

20.45

4.35

hsa-miR-298

18.5

0.027

0.0001

−13.29

hsa-miR-551b

73

0.029

594.24

9.21

Hsa-miR-545

73

0.031

17.08

4.09

Hsa-miR-375

19

0.038

0.003

−8.38

Hsa-miR-10b

19

0.039

0.29

−1.79

Hsa-miR-145

71.5

0.042

30.74

4.94

Hsa-miR-483-5p

19.5

0.043

0.4

−1.32

Hsa-let-7a

70.5

0.044

42.02

5.39

Mmu-miR-187

71

0.045

31.91

5.00

Hsa-miR-154

20.5

0.045

0.008

−6.97

CXCR3

10

0.0008

0.05

−4.32

TLR3

13

0.016

0.19

−2.39

LEFTY2

70

0.02

2.64

1.4

TNFSF4

67.5

0.035

6.01

2.59

CD70

17

0.038

0.12

−3.06

EREG

67

0.038

51.93

5.70

CD80

17

0.038

0.17

−2.56

miRNA

U value

p value

Ratio (higher ICP/lower ICP)

Fold change (log2 ratio)

hsa-miR-9

75.5

0.018

24.89

4.64

hsa-miR-16

71

0.045

25.89

4.69

STAT5B

70.5

0.006

106.98

6.74

TGM2

67.5

0.011

58.04

5.86

CD86 (CD80)

12.5

0.018

0.03

−5.06

S100A9

62.5

0.036

91.53

6.52

RIPK2

16

0.048

0.11

3.18