Fig. 2: Measures of the three by-products of heme degradation by the hemoglobin oxygenase enzymes in 20 male participants before, during and after 60 days of bed rest HDT. | npj Microgravity

Fig. 2: Measures of the three by-products of heme degradation by the hemoglobin oxygenase enzymes in 20 male participants before, during and after 60 days of bed rest HDT.

From: Six degrees head-down tilt bed rest caused low-grade hemolysis: a prospective randomized clinical trial

Fig. 2

a Endogenous CO elimination was elevated at all time points during bed rest. b Iron levels were elevated after 20 days of bed rest and decreased below baseline after bed rest. c Bilirubin was elevated at all time points during bed rest. These findings support low-grade hemolysis with enforcing and maintaining the bed rest position. Data expressed as changes from baseline. Shaded area represents the bed rest HDT phase. BDC baseline data collection, HDT head-down tilt, R recovery or reambulation. Error bars: 95% confidence interval. *p < 0.05 compared to baseline.

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