Fig. 2: Cytokines showing higher expression in hippocampus due to isolation and mitigation in MCAT mice. | npj Microgravity

Fig. 2: Cytokines showing higher expression in hippocampus due to isolation and mitigation in MCAT mice.

From: Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation

Fig. 2

a Eleven out of 44 cytokines were upregulated in wild-type single housed vs social-housed mice and mitigated in MCAT single housed mice. b Representative graph (IL-6) of one of the 11 cytokines elevated due to isolation and mitigated in MCAT mice. Here and in succeeding dot plots, the longer horizontal line in the dot plot corresponds to the group mean while the shorter horizontal lines depict the standard error (SE). Sample sizes are WT NL social (n = 6), WT NL single (n = 3), MCAT NL social (n = 6), and MCAT NL single (n = 4). Some data points overlap. A fit model was generated to include housing state, genotype, loading state, and their pairwise interactions. Interaction effects between housing state and genotype were assessed at p < 0.05. *Statistically significant at p < 0.05 by Tukey post hoc test.

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