Table 1 Responses of soleus (Sol) muscle proteins involved in metabolic processes to microgravity (µ-g) or artificial 1-g (A1-g) exposure and/or fructo-oligosaccharide (FOS) ingestion.
Gene symbol (accession) | µ-g & FOS (−)/A1-g & FOS (−) | µ-g & FOS (+)/A1-g & FOS (−) | A1-g & FOS (+)/A1-g & FOS (−) |
|---|---|---|---|
Glycolytic process | |||
Aldoa (P05064) | * FC = 1.78, P = 1.5E−4 | * FC = 1.53, P = 4.8E−3 | FC = 0.96, P = 5.1E−1 |
Gpi1 (P06745) | * FC = 1.76, P = 2.8E−3 | * FC = 1.80, P = 3.8E−3 | FC = 1.09, P = 3.5E−1 |
Gapdh (P16858) | * FC = 1.53, P = 6.8E−3 | FC = 1.53, P = 3.7E−2 | FC = 1.04, P = 8.2E−1 |
Pfkm (P47857) | * FC = 1.21, P = 3.8E−3 | FC = 1.02, P = 6.8E−1 | FC = 0.90, P = 6.4E−2 |
Pgk1 (P09411) | * FC = 1.62, P = 8.8E−4 | * FC = 1.69, P = 7.9E−3 | * FC = 1.18, P = 5.8E−3 |
Pgk2 (P09041) | * FC = 3.04, P = 3.7E−3 | FC = 2.97, P = 1.1E−2 | FC = 1.48, P = 5.9E−2 |
Pkm (P52480) | * FC = 1.46, P = 2.5E−3 | FC = 1.37, P = 1.4E−2 | FC = 1.05, P = 4.2E−1 |
Fatty acid beta-oxidation | |||
Acat1 (Q8QZT1) | * FC = 0.68, P = 2.9E−4 | * FC = 0.75, P = 2.2E−3 | FC = 0.93, P = 8.3E−2 |
Acaa1b (Q8VCH0) | * FC = 0.59, P = 8.2E−3 | FC = 0.76, P = 1.3E−1 | FC = 0.85, P = 2.3E−1 |
Acaa2 (Q8BWT1) | * FC = 0.63, P = 1.8E−3 | * FC = 0.71, P = 1.0E−3 | FC = 0.95, P = 2.7E−1 |
Acad10 (Q8K370) | FC = 0.74, P = 1.1E−2 | * FC = 0.80, P = 1.6E−3 | FC = 0.94, P = 3.6E−1 |
Acadl (P51174) | FC = 0.78, P = 1.1E−2 | * FC = 0.85, P = 9.5E−4 | FC = 0.94, P = 1.6E−1 |
Acadm (P45952) | * FC = 0.53, P = 1.5E−3 | * FC = 0.61, P = 2.8E−4 | FC = 0.94, P = 2.3E−1 |
Acadsb (Q9DBL1) | * FC = 0.70, P = 5.9E−3 | FC = 0.83, P = 6.4E−2 | FC = 0.90, P = 2.8E−1 |
Acadvl (P50544) | * FC = 0.69, P = 3.4E−4 | * FC = 0.78, P = 4.1E−3 | FC = 0.93, P = 1.7E−1 |
Acox1 (Q9R0H0) | * FC = 0.15, P = 8.0E−4 | * FC = 0.20, P = 1.9E−3 | FC = 0.88, P = 5.2E−1 |
Cpt1b (Q924X2) | * FC = 0.71, P = 3.0E−3 | FC = 0.74, P = 1.6E−2 | FC = 1.02, P = 7.4E−1 |
Decr1 (Q9CQ62) | * FC = 0.68, P = 1.3E−3 | * FC = 0.77, P = 6.0E−3 | FC = 0.98, P = 7.3E−1 |
Etfa (Q99LC5) | * FC = 0.72, P = 3.0E−3 | FC = 0.88, P = 5.1E−2 | FC = 0.95, P = 3.3E−1 |
Etfdh (Q921G7) | * FC = 0.70, P = 2.2E−3 | FC = 0.80, P = 1.1E−2 | FC = 0.96, P = 5.8E−1 |
Ech1 (O35459) | * FC = 0.38, P = 6.1E−4 | * FC = 0.46, P = 1.1E−3 | FC = 0.92, P = 3.7E−1 |
Eci1 (P42125) | * FC = 0.64, P = 1.8E−3 | * FC = 0.72, P = 1.1E−3 | FC = 0.93, P = 3.4E−1 |
Eci2 (Q9WUR2) | * FC = 0.71, P = 1.5E−3 | FC = 0.81, P = 1.8E−2 | FC = 0.99, P = 7.7E−1 |
Hadh (Q61425) | * FC = 0.63, P = 3.4E−3 | * FC = 0.74, P = 6.4E−3 | FC = 0.88, P = 1.3E−1 |
Hadha (Q8BMS1) | * FC = 0.62, P = 1.6E−4 | FC = 0.74, P = 1.5E−2 | FC = 0.97, P = 6.2E−1 |
Hadhb (Q99JY0) | * FC = 0.65, P = 9.9E−5 | FC = 0.78, P = 1.3E−2 | FC = 0.95, P = 4.5E−1 |
Hibch (Q8QZS1) | * FC = 0.74, P = 2.2E−3 | FC = 0.87, P = 2.2E−2 | FC = 0.94, P = 5.4E−2 |
Tricarboxylic acid cycle | |||
Cs (Q9CZU6) | * FC = 0.79, P = 6.5E−4 | * FC = 0.87, P = 2.7E−3 | FC = 0.93, P = 5.4E−2 |
Dlat (Q8BMF4) | * FC = 0.74, P = 5.0E−3 | FC = 0.83, P = 1.1E−2 | FC = 0.92, P = 2.0E−1 |
Dlst (Q9D2G2) | * FC = 0.75, P = 3.8E−3 | * FC = 0.81, P = 7.4E−3 | FC = 0.90, P = 8.6E−2 |
Fh1 (P97807) | * FC = 0.81, P = 5.9E−3 | FC = 1.00, P = 1.0 | FC = 0.88, P = 4.8E−2 |
Idh2 (P54071) | * FC = 0.57, P = 4.4E−4 | * FC = 0.70, P = 3.9E−3 | FC = 1.04, P = 6.6E−1 |
Idh3g (P70404) | * FC = 0.76, P = 7.1E−3 | FC = 0.82, P = 1.7E−2 | FC = 0.85, P = 2.1E−2 |
Mdh2 (P08249) | * FC = 0.82, P = 4.1E−3 | FC = 0.91, P = 1.6E−1 | FC = 0.91, P = 6.4E−2 |
Ogdh (Q60597) | * FC = 0.74, P = 7.8E−4 | * FC = 0.83, P = 3.7E−3 | FC = 0.88, P = 1.1E−1 |
Pdhb (Q9D051) | * FC = 0.82, P = 5.2E−3 | FC = 0.91, P = 5.5E−2 | FC = 0.92, P = 2.3E−1 |
Sdha (Q8K2B3) | * FC = 0.82, P = 7.4E−3 | FC = 0.89, P = 7.5E−2 | FC = 0.91, P = 1.8E−1 |
Mitochondrial electron transport | |||
Cox2 (P00405) | * FC = 0.69, P = 6.9E−3 | FC = 0.78, P = 3.0E−2 | FC = 0.84, P = 1.0E−1 |
Cox4i1 (P19783) | * FC = 0.78, P = 1.6E−3 | * FC = 0.80, P = 4.0E−3 | FC = 0.91, P = 1.4E−1 |
Cox5a (P12787) | * FC = 0.76, P = 7.7E−3 | FC = 0.87, P = 1.6E−1 | FC = 1.03, P = 7.8E−1 |
(Cox5b (P19536) | * FC = 0.82, P = 8.5E−3 | FC = 0.90, P = 3.8E−1 | FC = 0.96, P = 6.2E−1 |
Cox7c (P17665) | * FC = 0.68, P = 4.7E−3 | FC = 0.81, P = 4.2E−2 | FC = 0.92, P = 4.7E−1 |
Cycs (P62897) | * FC = 0.66, P = 1.6E−3 | * FC = 0.70, P = 8.6E−3 | FC = 0.95, P = 4.0E−1 |
Pmpcb (Q9CXT8) | * FC = 0.62, P = 2.9E−3 | FC = 0.86, P = 4.8E−1 | FC = 0.81, P = 1.0E−1 |
Uqcrc2 (Q9DB77) | * FC = 0.83, P = 2.5E−4 | FC = 0.91, P = 1.7E−1 | FC = 0.89, P = 8.6E−2 |
