Table 2 Responses of soleus (Sol) muscle proteins involved in glutathione-mediated detoxification and glutathione redox reactions to microgravity (µ-g) or artificial 1-g (A1-g) exposure and/or fructo-oligosaccharide (FOS) ingestion.

From: Effects of microgravity exposure and fructo-oligosaccharide ingestion on the proteome of soleus and extensor digitorum longus muscles in developing mice

Gene symbol (accession)

µ-g & FOS (−)/A1-g & FOS (−)

µ-g & FOS (+)/A1-g & FOS (−)

A1-g & FOS (+)/A1-g & FOS (−)

Gpx1 (P11352)

FC = 1.26, P = 5.0E−2

* FC = 1.55, P = 6.1E−3

FC = 1.03, P = 6.4E−1

Gpx3 (P46412)

* FC = 2.89, P = 9.4E−4

* FC = 3.55, P = 1.2E−4

FC = 1.08, P = 1.7E−1

Gsr (P47791)

* FC = 1.43, P = 4.1E−3

* FC = 1.38, P = 5.7E−3

FC = 1.04, P = 8.9E−1

Gstk1 (Q9DCM2)

* FC = 0.77, P = 1.5E−4

FC = 1.02, P = 8.0E−1

FC = 0.99, P = 8.3E−1

Gstm1 (P10649)

* FC = 1.91, P = 1.5E−4

* FC = 2.02, P = 3.4E−4

FC = 1.00, P = 9.1E−1

Gstm2 (P15626)

* FC = 1.64, P = 1.7E−3

* FC = 1.83, P = 6.0E−4

FC = 0.96, P = 6.0E−1

Gstm5 (P48774)

FC = 1.20, P = 1.4E−2

* FC = 1.48, P = 6.2E−4

FC = 0.99, P = 8.1E−1

Gsto1 (O09131)

FC = 0.87, P = 1.4E−1

FC = 0.97, P = 6.3E−1

* FC = 1.26, P = 6.3E−3

Gstp1 (P19157)

* FC = 1.82, P = 9.9E−4

* FC = 2.50, P = 1.4E−3

FC = 1.39, P = 4.9E−2

  1. The protein abundance profiles of the groups exposed to µ-g with and without FOS ingestion and the group exposed to A1-g with FOS ingestion were individually compared with that of the group exposed to A1-g without FOS ingestion. The results for the proteins, which were categorized as the related factors to glutathione metabolic process, glutathione-mediated detoxification and/or glutathione redox reactions by DAVID Bioinformatics Resources 6.8 and Ingenuity Pathway Analysis and significantly (p < 0.01) affected by µ-g exposure and/or FOS ingestion, in Sol muscles are indicated. The fold change (FC) and p value (P) of each protein are depicted. *: the significant high- or low-abundance proteins.
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