Fig. 2: Spaceflight-induced changes in max load of bone in rodent.
From: Bone strength and composition in spacefaring rodents: systematic review and meta-analysis
a Forest plot of changes in max load in humerus, femur and tibia in spaceflight animals (SF) compared to ground control (GC) (Left); and GC compared to vivarium control animals (VC) (Right). Missions are ordered by mission year; mission name, duration (Days), SF and GC sample sizes (nSF/nGC) are shown. Circle/line: effect size (%) and 95% CI, the size of the circle is proportional to the mission’s weight. Black diamonds: overall effect size and 95% CI for rats; color diamonds: overall effect size and 95% CI for rodents. I2 and H2 are for rodents. *indicates missions where there was no GC, and SF was compared to VC. b Subgroup analysis of measured max load by mechanical test: torsional test (Torsional) and 3-point bending tests (3PBT). Square/line: effect size (%) and 95% CI. Ni: number of mission level outcomes. Meta-regression analysis of max load measures obtained by 3PBT as a function of loading rate (c) and span length (d) of the 3PBT machinery. Linear regression line (dark blue), its 95% CI (light blue area) and R2 are shown.
