Fig. 7: Network representation of differential expressed genes altered in both spaceflight and aging datasets and their association with core-clock elements.
From: Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent
206 common genes were differentially expressed in at least one of (a) the long-term spaceflight datasets (37 days) and (b) in extreme age groups (older vs. young). In addition, core-clock elements (bold circles with red border) were also added to the network to explore the regulatory role of circadian clock machinery. Network analysis was carried out using STRING and MCODE, cytoscape based plugins. The same gene sets were plotted for (c) fasting and (d) exercise datasets. The gene sets were color coded based on their up- or down-regulation compared to their respective controls. Set of genes that depicted similar pattern (up or down-regulation) in spaceflight and aging datasets were shown as rectangles. Genes with no differential expression are represented as white circles.
