Table 1 Ferroptosis pathway genes modulated by microgravity.

From: Microgravity triggers ferroptosis and accelerates senescence in the MG-63 cell model of osteoblastic cells

Ensembl ID

Gene symbol

Gene name

Log2 fold change

Fold change

p value

ENSG00000165029

ABCA1

ATP binding cassette subfamily A member 1

2.805

6.989

2.33E-44

ENSG00000068366

ACSL4

Acyl-CoA synthetase long-chain family member 4

1.979

3.942

2.41E-55

ENSG00000167772

ANGPTL4

Angiopoietin like 4

1.983

3.953

6.80E-11

ENSG00000168374

ARF4

ADP ribosylation factor 4

1.185

2.274

2.96E-13

ENSG00000128272

ATF4

Activating transcription factor 4

1.079

2.113

3.29E-09

ENSG00000124762

CDKN1A

Cyclin-dependent kinase inhibitor 1A

1.149

2.218

1.66E-21

ENSG00000128965

CHAC1

ChaC glutathione specific gamma-glutamylcyclotransferase 1

1.943

3.845

7.22E-13

ENSG00000172071

EIF2AK3

Eukaryotic translation initiation factor 2 alpha kinase 3

1.220

2.329

2.27E-10

ENSG00000144554

FANCD2

FA complementation group D2

–1.326

0.399

1.89E-24

ENSG00000167996

FTH1

Ferritin heavy chain 1

2.654

6.294

1.03E-63

ENSG00000087086

FTL

Ferritin light chain

1.532

2.892

2.52E-25

ENSG00000001084

GCLC

Glutamate-cysteine ligase catalytic subunit

1.030

2.042

4.00E-10

ENSG00000184270

H2AC21

H2A clustered histone 21

–1.278

0.412

1.08E-09

ENSG00000105968

H2AZ2

H2A.Z variant histone 2

–1.012

0.496

3.60E-34

ENSG00000278588

H2BC10

H2B clustered histone 10

–1.256

0.419

1.48E-10

ENSG00000274641

H2BC17

H2B clustered histone 17

–1.592

0.332

2.90E-28

ENSG00000162409

PRKAA2

Protein kinase AMP-activated catalytic subunit alpha 2

1.104

2.149

5.47E-14

ENSG00000080839

RBL1

RB transcriptional corepressor like 1

–1.104

0.465

8.84E-15

ENSG00000130066

SAT1

Spermidinespermine N1-acetyltransferase 1

2.722

6.598

2.71E-38

ENSG00000138821

SLC39A8

Solute carrier family 39 member 8

1.304

2.469

6.24E-06

ENSG00000104635

SLC39A14

Solute carrier family 39 member 14

1.731

3.320

3.24E-32

ENSG00000151012

SLC7A11

Solute carrier family 7 member 11

1.282

2.432

1.21E-09

ENSG00000161011

SQSTM1

Sequestosome 1

1.519

2.866

9.02E-31

  1. List of genes modulated by a |log2 fold change| > 1 (fold change >2 or <0.5). Analysis cut-off: base mean count >100, adj p value <0.001. Expression p values were calculated based on the Benjamini–Hochberg procedure.
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