Table 2 Senescence pathway genes modulated by microgravity.

ENSG00000162772

ATF3

Activating transcription factor 3

2.605

6.084

3.35E-32

ENSG00000134107

BHLHE40

Basic helix-loop-helix family member e40

1.835

3.568

6.50E-26

ENSG00000149260

CAPN5

Calpain 5

–1.035

0.488

1.01E-16

ENSG00000173894

CBX2

Chromobox 2

–1.003

0.499

3.76E-14

ENSG00000134057

CCNB1

Cyclin B1

–1.438

0.369

4.20E-26

ENSG00000157456

CCNB2

Cyclin B2

–1.347

0.393

1.21E-24

ENSG00000175305

CCNE2

Cyclin E2

–1.422

0.373

1.45E-30

ENSG00000164045

CDC25A

Cell division cycle 25A

–1.136

0.455

3.49E-11

ENSG00000158402

CDC25C

Cell division cycle 25C

–1.383

0.383

7.74E-18

ENSG00000170312

CDK1

Cyclin-dependent kinase 1

–1.283

0.411

3.29E-23

ENSG00000124762

CDKN1A

Cyclin-dependent kinase inhibitor 1A

1.149

2.218

1.66E-21

ENSG00000172216

CEBPB

CCAAT enhancer binding protein beta

1.593

3.017

2.11E-20

ENSG00000169429

CXCL8

C-X-C motif chemokine ligand 8

3.415

10.666

5.07E-23

ENSG00000101412

E2F1

E2F transcription factor 1

–1.641

0.321

1.58E-21

ENSG00000007968

E2F2

E2F transcription factor 2

–2.074

0.238

1.54E-36

ENSG00000133740

E2F5

E2F transcription factor 5

1.232

2.349

6.77E-13

ENSG00000165891

E2F7

E2F transcription factor 7

–1.667

0.315

6.67E-29

ENSG00000129173

E2F8

E2F transcription factor 8

–1.754

0.296

6.04E-13

ENSG00000106462

EZH2

Enhancer of zeste 2 polycomb repressive complex 2 subunit

–1.396

0.380

7.83E-28

ENSG00000099860

GADD45B

Growth arrest and DNA damage-inducible beta

1.461

2.753

1.22E-10

ENSG00000105856

HBP1

HMG-box transcription factor 1

1.443

2.719

2.85E-13

ENSG00000136244

IL6

Interleukin 6

5.317

39.864

1.20E-84

ENSG00000115008

IL1A

Interleukin 1 alpha

2.978

7.879

6.93E-23

ENSG00000113368

LMNB1

Lamin B1

–1.580

0.334

3.36E-40

ENSG00000196611

MMP1

Matrix metallopeptidase 1

1.341

2.533

1.46E-05

ENSG00000149968

MMP3

Matrix metallopeptidase 3

2.763

6.788

2.83E-10

ENSG00000004799

PDK4

Pyruvate dehydrogenase kinase 4

3.724

13.214

1.62E-36

ENSG00000119403

PHF19

PHD finger protein 19

–1.379

0.384

1.04E-35

ENSG00000080839

RBL1

RB transcriptional corepressor like 1

–1.104

0.465

8.84E-15

ENSG00000162302

RPS6KA4

Ribosomal protein S6 kinase A4

–1.113

0.462

2.08E-18

ENSG00000137834

SMAD6

SMAD family member 6

–1.722

0.303

2.07E-21

ENSG00000101665

SMAD7

SMAD family member 7

1.042

2.059

1.13E-11

ENSG00000112096

SOD2

Superoxide dismutase 2

1.787

3.451

7.63E-06

ENSG00000161011

SQSTM1

Sequestosome 1

1.519

2.866

9.02E-31

ENSG00000119699

TGFB3

Transforming growth factor beta 3

1.655

3.149

1.90E-04

ENSG00000137462

TLR2

Toll like receptor 2

1.378

2.599

4.74E-06

ENSG00000185650

ZFP36L1

ZFP36 ring finger protein like 1

1.081

2.116

1.58E-31