Fig. 2: The antioxidant/anti-inflammatory cocktail does not protect the cerebral autoregulation from the effects of long-term head-down bedrest (HDBR).

a HDBR induced an increase in arterial pressure at the level of the middle cerebral artery (BPMCA, light blue circles, light blue line) relative to baseline (BCD-2) during the 60-day study period (ΔBPMCA). b HDBR decreased cerebral blood flow velocity (CBFV, green circles, green line) relative to BCD-2 during the 60-day study period (ΔCBFV). c HDBR induced a decrease in cerebrovascular resistance index (CVRi, orange circles, orange line) relative to BCD-2 during the 60-day study period (ΔCVRi). d The HDBR-induced changes in BPMCA in the antioxidant/anti-inflammatory cocktail group (brown diamonds, full brown line) were statistically not different from the HDBR-induced changes in BPMCA in the control group (gray triangles, dashed gray line). e The HDBR-induced changes in CBFV in the antioxidant/anti-inflammatory cocktail group (brown diamonds, full brown line) were statistically not different from the HDBR-induced changes in CBFV in the control group (gray triangles, dashed gray line). f The HDBR-induced changes in CVRi in the antioxidant/anti-inflammatory cocktail group (brown diamonds, full brown line) were statistically not different from the HDBR-induced changes in CVRi in the control group (gray triangles, dashed gray line). Circles represent the effect estimates from the mixed-effect model, error bars represent the 95% confidence intervals. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 vs BCD-2.