Fig. 5: Transdermal insulin delivery systems.
From: Hydrogel-based flexible materials for diabetes diagnosis, treatment, and management
a Insulin release is triggered from the core matrix of PVA-TSPBA microneedle array patch by a hyperglycemic state91. b Blood glucose level of diabetic mice treated with microneedle array-array patches. Blue arrow indicates administration of microneedle array; red arrow indicates removal of microneedle. c Inclusion of PBA-PLGA MPs into DOP-HA hydrogel to form MP-gel93. d Therapeutic efficacy of insulin-loaded MP-gel in diabetic mice model. Reproduced with permission from refs. 91,93. Copyright 2018 American Chemical Society and 2017 Elsevier.
